Vlasov V, Erokhin V, Filipenko L
Eksp Med Morfol. 1990;29(3):30-2.
The authors report on diagnosis of two cases with alveolar lipoproteinosis, using materials from transbronchial lung biopsy and bronchoalveolar lavage. Light microscopic examination of the materials showed accumulation of fine-grained substance in the alveolar cavity which was stained intensively in red after PAS reaction and toluidin blue. Heterogeneous material was established in the alveoli by the electro microscope. Noncellular components were represented by single round membranes, not large parts of tubular myelin or osmiophilic strata bodies. The cellular component was presented mainly by alveolar macrophages with not well developed lysosomal apparatus (primary lysosomes), slightly manifested elements of Golgi complex, moderately developed cytoplasmatic reticulum. Many of the macrophages had preserved phagocytic activity-presence of pino- and phagocytic vacuoles.
作者报告了两例肺泡蛋白沉积症的诊断情况，使用了经支气管肺活检和支气管肺泡灌洗的材料。对这些材料进行光镜检查显示，肺泡腔内有细颗粒物质积聚，经PAS反应和甲苯胺蓝染色后呈深红色。电镜检查发现肺泡内有不均一物质。非细胞成分表现为单个圆形膜，而非大量的管状髓鞘或嗜锇层状体。细胞成分主要是肺泡巨噬细胞，其溶酶体装置发育不完善（初级溶酶体），高尔基体复合体的表现轻微，细胞质内质网发育中等。许多巨噬细胞保留了吞噬活性——存在吞饮和吞噬空泡。
