下颌磨牙牙龈外周型成釉细胞瘤：一例报告及免疫组织化学研究

Peripheral ameloblastoma of the lower molar gingiva: a case report and immunohistochemical study.

作者信息

Kato Hisashi, Ota Yoshihide, Sasaki Masashi, Karakida Kazunari, Kaneko Akihiro, Sekido Yasutomo, Tsukinoki Keiichi

机构信息

Department of Oral and Maxillofacial Surgery Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.

出版信息

Tokai J Exp Clin Med. 2012 Jul 20;37(2):30-4.

PMID:22763824

Abstract

Peripheral ameloblastoma (PA) is a rare extraosseous odontogenic tumor with histological characteristics similar to those of the common intraosseous ameloblastoma. Two questions regarding PA remain: its histogenic origin and how to differentiate between PA and intraoral basal cell carcinoma. We describe a patient with PA. The result of immunohistochemistry showed cytokeratin (CK) 7-, CK14+, CK19+, AE1/AE3+, CAM5.2-, 34 β E12+, epithelial membrane antigen-, Ber-EP4-, p53-, p63+, and low Ki-67, that was similar to those of 4 cases of intraosseous ameloblastoma. Our results suggest that a PA originates from odontogenic epithelial remnants, rather than from the oral epithelium.

摘要

外周性成釉细胞瘤（PA）是一种罕见的骨外牙源性肿瘤，其组织学特征与常见的骨内成釉细胞瘤相似。关于PA仍存在两个问题：其组织发生起源以及如何鉴别PA与口腔基底细胞癌。我们描述了1例PA患者。免疫组化结果显示细胞角蛋白（CK）7阴性、CK14阳性、CK19阳性、AE1/AE3阳性、CAM5.2阴性、34βE12阳性、上皮膜抗原阴性、Ber-EP4阴性、p53阴性、p63阳性以及Ki-67低表达，这与4例骨内成釉细胞瘤的结果相似。我们的结果提示，PA起源于牙源性上皮残余，而非口腔上皮。