Mydlík Miroslav, Derzsiová Katarína, Bohus Branislav
IVth Internal Clinic, University Hospital of L. Pasteur and Medical School of P. J. Safárik University, Kosice, Slovak Republic.
Przegl Lek. 2012;69(1):1-4.
Renal functions were investigated in 29 marathon runners and in 20 runners in connection with 16-kilometre long-distance run. Body weight in runners decreased after marathon run in average of 1.3 +/- 0.5 kg and after 16-kilometre long-distance run in average of 1.4 +/- 0.4 kg. Blood pressure decreased after both runs. Total proteinuria and albuminuria significantly increased after both runs. The significant non-glomerular erythrocyturia was found in 9 runners after marathon run and in 3 runners after 16-km long-distance run. Total catalytic activity of serum creatine kinase, and its isoenzyme MB significantly increased after both runs. Increase of isoenzyme MB creatine kinase after runs was lower than 6% of total catalytic activity of creatine kinase. These increases were caused by rhabdomyolysis and were connected with myoglobinuria. Serum myoglobin significantly increased after marathon run and after 16-km run. Serum urea, creatinine, phosphorus and osmolality significantly increased after both runs. Calculated GFR significantly decreased after both runs. FE(Na), FE(Ca), FE(P), FE(OSM) and FE(H2O) significantly decreased after both runs. FE significantly increased after marathon run, but after 16-km run non-significantly decreased. Renal function abnormalities were caused by dehydration, microtraumas in extrarenal urinary tract, protein catabolism, decreased urinary excretion of osmotically active substances, rhabdomyolysis, activation of renin-angiotensin-aldosterone system and other factors. Renal function abnormalities in runners were already not present 2-6 days after marathon run and after 16-kilometre long-distance run and investigated parameters were in normal range or they did not significantly differ from the initial values.
对29名马拉松运动员和20名参加16公里长跑的运动员的肾功能进行了研究。马拉松赛后运动员体重平均下降1.3±0.5kg，16公里长跑后平均下降1.4±0.4kg。两次跑步后血压均下降。两次跑步后总蛋白尿和白蛋白尿均显著增加。9名马拉松赛后运动员和3名16公里长跑后运动员出现显著的非肾小球性红细胞尿。两次跑步后血清肌酸激酶及其同工酶MB的总催化活性均显著增加。跑步后肌酸激酶同工酶MB的增加低于肌酸激酶总催化活性的6%。这些增加是由横纹肌溶解引起的，并与肌红蛋白尿有关。马拉松赛后和16公里跑步后血清肌红蛋白显著增加。两次跑步后血清尿素、肌酐、磷和渗透压均显著增加。两次跑步后计算的肾小球滤过率显著降低。两次跑步后FE(Na)、FE(Ca)、FE(P)、FE(OSM)和FE(H2O)均显著降低。马拉松赛后FE显著增加，但16公里跑步后无显著下降。肾功能异常是由脱水、肾外尿路微创伤、蛋白质分解代谢、渗透性活性物质尿排泄减少、横纹肌溶解、肾素-血管紧张素-醛固酮系统激活及其他因素引起的。马拉松赛后和16公里长跑后2至6天，跑步者的肾功能异常已不存在，所研究参数在正常范围内或与初始值无显著差异。
