Blomain Erik S, McMahon Steven B
Department of Cancer Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19104, USA.
Biochim Biophys Acta. 2012 Sep-Oct;1819(9-10):1075-9. doi: 10.1016/j.bbagrm.2012.06.004. Epub 2012 Jul 3.
Eukaryotes control nearly every cellular process in part by modulating the transcription of genes encoded by their nuclear genome. However, these cells are faced with the added complexity of possessing a second genome, within the mitochondria, which encodes critical components of several essential processes, including energy metabolism and macromolecule biosynthesis. As these cellular processes require gene products encoded by both genomes, cells have adopted strategies for linking mitochondrial gene expression to nuclear gene expression and other dynamic cellular events. Here we discuss examples of several mechanisms that have been identified, by which eukaryotic cells link extramitochondrial signals to dynamic alterations in mitochondrial transcription. This article is part of a Special Issue entitled: Mitochondrial Gene Expression.
真核生物通过调节其核基因组所编码基因的转录，在一定程度上控制着几乎每一个细胞过程。然而，这些细胞面临着额外的复杂性，因为它们的线粒体内存在第二个基因组，该基因组编码了包括能量代谢和大分子生物合成在内的几个基本过程的关键组分。由于这些细胞过程需要两个基因组所编码的基因产物，细胞已经采用了一些策略，将线粒体基因表达与核基因表达以及其他动态细胞事件联系起来。在这里，我们讨论已确定的几种机制的例子，通过这些机制，真核细胞将线粒体外信号与线粒体转录的动态变化联系起来。本文是名为“线粒体基因表达”的特刊的一部分。
