Pincus Maike, Arck Petra
Department of Pediatrics, Pneumology and Immunology Division, Charité Universitaetsmedizin Berlin, Berlin, Germany.
Chem Immunol Allergy. 2012;98:70-84. doi: 10.1159/000336499. Epub 2012 Jun 26.
Emerging evidence reveals that the incidence of allergic disorders commencing during childhood is influenced by pre-, peri- and early postnatal environmental challenges. We here highlight biomarkers involved in the purported interaction of a challenged intrauterine environment during pregnancy and the risk for allergies in the children later in life. We propose that the identification of biomarkers during pregnancy may allow early detection of children prone to develop allergies and possibly other chronic immune diseases. Subsequently, therapeutic interventions designed to prevent negative consequences of prenatal environmental challenges on children's immune system would be within reach.
新出现的证据表明，儿童期开始的过敏性疾病发病率受产前、围产期和产后早期环境挑战的影响。我们在此强调与孕期子宫内环境受到挑战和儿童日后发生过敏风险之间所谓相互作用有关的生物标志物。我们提出，孕期生物标志物的识别可能有助于早期发现易患过敏及可能其他慢性免疫疾病的儿童。随后，旨在预防产前环境挑战对儿童免疫系统产生负面影响的治疗干预措施将触手可及。
