Reineke U, Hühnerschulte M, Ebmeyer J, Sudhoff H
Klinik für Hals-Nasen-Ohren-Heilkunde, Kopf- und Halsschirurgie, Klinikum Bielefeld, Teutoburger Str. 50, 33604, Bielefeld, Deutschland.
HNO. 2013 Apr;61(4):314-20. doi: 10.1007/s00106-012-2531-0.
The pathogenesis of idiopathic sudden sensorineural hearing loss (ISSHL) still remains unclear. This retrospective study was performed to evaluate the effectiveness of tympanotomy and sealing of the round window membrane after unilateral idiopathic sudden sensorineural hearing loss.
A total of 74 patients with idiopathic sudden sensorineural hearing loss were treated with antiphlogistic-rheologic infusion therapy according to Stennert (steroids and pentoxyphylline). In addition, all patients underwent exploratory tympanotomy and sealing of the round window membrane. Pure tone audiometry was performed pre- and postinterventionally.
The average hearing loss (four pure tone average) of all patients was 58.9 dB pre-, and 46 dB postinterventionally, which is an average improvement of 12.9 dB. Patients with hearing loss of more than 60% improved significantly compared to patients with hearing loss less than 60% (33.9% vs. +3.3%). Sealing of the round window membrane was found to be more effective when performed within 8 days after ISSHL. A membrane rupture did not lead to better therapy results. No significant correlation was found between therapy outcome and other clinical symptoms.
Sealing of the window membrane shows equal results to conservative methods. If patients with hearing loss of more than 60% have more benefit in tympanotomy with sealing of the window membrane than patients with less hearing loss--as shown as in this study--has to be proved in randomized examinations. Intraoperatively found ruptures of the round window membrane had no significant effect on the therapy outcome.
特发性突发性感音神经性听力损失(ISSHL)的发病机制仍不清楚。本回顾性研究旨在评估单侧特发性突发性感音神经性听力损失后鼓室切开术及圆窗膜封闭术的有效性。
74例特发性突发性感音神经性听力损失患者按照施泰纳特疗法(类固醇和己酮可可碱)接受抗炎-改善血液流变学的输液治疗。此外,所有患者均接受了鼓室探查术及圆窗膜封闭术。干预前后均进行了纯音听力测定。
所有患者干预前平均听力损失(四个纯音平均值)为58.9dB,干预后为46dB,平均改善12.9dB。听力损失超过60%的患者与听力损失低于60%的患者相比改善显著(33.9%对+3.3%)。发现圆窗膜封闭术在ISSHL发生后8天内进行时效果更佳。膜破裂并未带来更好的治疗效果。未发现治疗结果与其他临床症状之间存在显著相关性。
圆窗膜封闭术与保守方法效果相当。如本研究所示,听力损失超过60%的患者在鼓室切开术及圆窗膜封闭术中是否比听力损失较轻的患者获益更多,必须通过随机试验加以证实。术中发现的圆窗膜破裂对治疗结果无显著影响。