Department of Pathology, San Cecilio University Hospital, 18012 Granada, Spain.
Pathol Res Pract. 2012 Aug 15;208(8):497-500. doi: 10.1016/j.prp.2012.05.018. Epub 2012 Jul 6.
A 20-year-old female with a diagnosis of autoimmune encephalitis against N-methyl-D-aspartate receptor was found to have a 13 mm teratoma in the left ovary. The tumor had undergone massive coagulative necrosis within a normal ovary, a previously unreported feature. Necrosis of a mature cystic teratoma is very rare in the absence of ovarian torsion. It is proposed that necrosis may have induced a massive liberation of neuronal antigens. The vast majority of the tumors associated with this newly described condition are ovarian teratomas containing neural tissues. In this paper, we review their different histopathological aspects that may explain the relative incidence of various tumor types associated to this form of encephalitis. Anti N-methyl-D-aspartate receptor encephalitis has now become the most frequent autoimmune disorder associated with ovarian teratoma.
一位 20 岁女性，自身免疫性脑炎诊断为 N-甲基-D-天冬氨酸受体，发现左卵巢有 13 毫米的畸胎瘤。肿瘤在正常卵巢内发生广泛凝固性坏死，这是一种以前未报道的特征。在没有卵巢扭转的情况下，成熟囊性畸胎瘤的坏死非常罕见。据推测，坏死可能导致大量神经元抗原释放。与这种新描述的情况相关的绝大多数肿瘤是含有神经组织的卵巢畸胎瘤。本文综述了其不同的组织病理学表现，这些表现可能解释了与这种脑炎相关的各种肿瘤类型的相对发病率。抗 N-甲基-D-天冬氨酸受体脑炎现已成为最常见的与卵巢畸胎瘤相关的自身免疫性疾病。
