Balikesir State Hospital, Balikesir, Turkey.
Peptides. 2012 Sep;37(1):161-4. doi: 10.1016/j.peptides.2012.06.012. Epub 2012 Jul 4.
Orexins have been implicated in the regulation of sleep-wake cycle, energy homeostasis, drinking behavior, analgesia, attention, learning and memory but their effects on epileptic activity are controversial. We investigated whether intracortical injections of orexin A (100 pmol) and B (100 pmol) cause epileptic activity in rats. We observed epileptic seizure findings on these two groups rats. Orexin A and B also significantly increased total EEG power spectrum. Our findings indicate that orexins cause epileptic activity.
食欲素参与睡眠-觉醒周期、能量平衡、饮水行为、镇痛、注意力、学习和记忆的调节，但它们对癫痫活动的影响存在争议。我们研究了内侧皮质注射食欲素 A（100pmol）和 B（100pmol）是否会引起大鼠癫痫活动。我们观察到这两组大鼠出现癫痫发作。食欲素 A 和 B 还显著增加了总 EEG 功率谱。我们的发现表明食欲素会引起癫痫活动。
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