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本文引用的文献

1
Transient targeting of hypothalamic orexin neurons alleviates seizures in a mouse model of epilepsy.下丘脑食欲素神经元的瞬时靶向治疗可缓解癫痫小鼠模型的癫痫发作。
Nat Commun. 2024 Feb 10;15(1):1249. doi: 10.1038/s41467-024-45515-5.
2
Hypothalamic hamartoma: Epileptogenesis beyond the lesion?下丘脑错构瘤：病变之外的致痫性？
Epilepsia. 2017 Jun;58 Suppl 2:32-40. doi: 10.1111/epi.13755.
3
Orexin-A increases the firing activity of hippocampal CA1 neurons through orexin-1 receptors.食欲素A通过食欲素-1受体增加海马CA1神经元的放电活动。
J Neurosci Res. 2017 Jul;95(7):1415-1426. doi: 10.1002/jnr.23975. Epub 2016 Oct 31.
4
SB-334867, an orexin receptor 1 antagonist, decreased seizure and anxiety in pentylenetetrazol-kindled rats.SB-334867，一种食欲素受体1拮抗剂，可降低戊四氮点燃大鼠的癫痫发作和焦虑水平。
Fundam Clin Pharmacol. 2017 Apr;31(2):201-207. doi: 10.1111/fcp.12249. Epub 2016 Nov 23.
5
Coreleased orexin and glutamate evoke nonredundant spike outputs and computations in histamine neurons.共同释放的食欲素和谷氨酸在组胺能神经元中引发非冗余的动作电位输出和计算。
Cell Rep. 2014 May 8;7(3):697-704. doi: 10.1016/j.celrep.2014.03.055. Epub 2014 Apr 24.
6
The physiological role of orexin/hypocretin neurons in the regulation of sleep/wakefulness and neuroendocrine functions.食欲素/下丘脑分泌素神经元在睡眠/觉醒和神经内分泌功能调节中的生理作用。
Front Endocrinol (Lausanne). 2013 Mar 6;4:18. doi: 10.3389/fendo.2013.00018. eCollection 2013.
7
Orexins cause epileptic activity.食欲素引起癫痫活动。
Peptides. 2012 Sep;37(1):161-4. doi: 10.1016/j.peptides.2012.06.012. Epub 2012 Jul 4.
8
Orexin receptors: pharmacology and therapeutic opportunities.食欲素受体：药理学和治疗机会。
Annu Rev Pharmacol Toxicol. 2011;51:243-66. doi: 10.1146/annurev-pharmtox-010510-100528.
9
Differential expression of orexin receptors 1 and 2 in the rat brain.大鼠脑中食欲素受体1和2的差异表达。
J Comp Neurol. 2001 Jun 18;435(1):6-25. doi: 10.1002/cne.1190.
10
Neurons containing hypocretin (orexin) project to multiple neuronal systems.含有下丘脑泌素（食欲素）的神经元投射到多个神经体系。
J Neurosci. 1998 Dec 1;18(23):9996-10015. doi: 10.1523/JNEUROSCI.18-23-09996.1998.

Could the Lateral Hypothalamus Be a New Target for Therapeutic Intervention to Prevent Seizures?

作者信息

Goodman Jeffrey H

机构信息

Department of Developmental Neurobiology, NYS Institute for Basic Research in Developmental Disabilities Department of Physiology and Pharmacology, SUNY Downstate Health Sciences University.

Department of Neurology, SUNY Downstate Health Sciences University.

出版信息

Epilepsy Curr. 2025 Apr 30:15357597251337839. doi: 10.1177/15357597251337839.

DOI:10.1177/15357597251337839
PMID:40322486
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12043600/
Abstract
摘要