Groupe de Neurobiologie Cellulaire, Homéostasie cellulaire et pathologies, Faculté de Médecine, Limoges, France.
Ageing Res Rev. 2013 Jan;12(1):39-49. doi: 10.1016/j.arr.2012.06.008. Epub 2012 Jul 6.
Tau phosphorylation is regulated by a balance between tau kinase and phosphatase activities. Disruption of this equilibrium was suggested to be at the origin of abnormal tau phosphorylation and thereby that might contributes to tau aggregation. Thus, understanding the regulation modes of tau dephosphorylation is of high interest in determining the possible causes at the origin of the formation of tau aggregates and to elaborate protection strategies to cope with these lesions in AD. Among the possible and relatively specific interventions that reverse tau phosphorylation is the stimulation of certain tau phosphatases. Here, we reviewed tau protein phosphatases, their physiological roles and regulation, their involvement in tau phosphorylation and the relevance to AD. We also reviewed the most common compounds acting on each tau phosphatase including PP2A.
tau 磷酸化受 tau 激酶和磷酸酶活性之间的平衡调节。这种平衡的破坏被认为是异常 tau 磷酸化的起源，因此可能导致 tau 聚集。因此，了解 tau 去磷酸化的调节模式对于确定 tau 聚集形成的可能原因以及制定应对 AD 中这些损伤的保护策略具有重要意义。在可能的、相对特异的逆转 tau 磷酸化的干预措施中，有刺激某些 tau 磷酸酶。本文综述了 tau 蛋白磷酸酶的生理作用和调节、在 tau 磷酸化中的作用及其与 AD 的相关性。还综述了作用于每种 tau 磷酸酶的常见化合物，包括 PP2A。
