局部下颌骨朗格汉斯细胞组织细胞增生症的皮质类固醇瘤内注射治疗：两例报告。
Intralesional infiltration of corticosteroids in the treatment of localized Langerhans cell histiocytosis of the mandible: report of two cases.
机构信息
Associate Professor, Department of Oral and Maxillofacial Surgery, Yeouido St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Oct;116(4):e255-60. doi: 10.1016/j.oooo.2011.11.035. Epub 2012 Jul 6.
OBJECTIVE
This study was undertaken to describe 2 cases of localized Langerhans cell histiocytosis (LLCH) of the mandible that healed quickly following intralesional infiltration of corticosteroids.
STUDY DESIGN
Two patients with LLCH of the mandible were treated in a 1-stage procedure with intralesional injection of methylprednisolone. Symptoms of pain were quickly relieved and the swelling receded. Periodic orthopantomogram and computerized tomography after corticosteroid injection revealed continuous regression of mandibular osteolysis and a favorable osseous consolidation in the lesions.
CONCLUSIONS
The results of this report suggest that intralesional injection of corticosteroids should be the initial choice of treatment of LLCH of the mandible, especially in children to preserve tooth germs.
目的
本研究旨在描述 2 例下颌局灶性朗格汉斯细胞组织细胞增生症（LLCH）病例，其在接受皮质类固醇瘤内注射后迅速愈合。
研究设计
2 例下颌 LLCH 患者采用甲基强的松龙瘤内注射行 1 期治疗。疼痛症状迅速缓解，肿胀消退。皮质类固醇注射后定期进行曲面体层片和计算机断层扫描显示下颌骨溶骨性病变持续消退，病变处骨质有良好的骨整合。
结论
本报告结果表明，皮质类固醇瘤内注射应该是下颌 LLCH 的首选初始治疗方法，特别是对于儿童患者以保存牙胚。
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