Desablens B, Lesoin A, Bourret A, Peltier F, Sevestre H, Closset P
Maladies du Sang, CHRU, Hôpital Sud, Amiens.
J Gynecol Obstet Biol Reprod (Paris). 1990;19(7):857-61.
We report a case history of a woman of 66 years of age who had a granulocytic sarcoma of the cervix which presented as metrorrhagia and which at first was thought to be an anaplastic cancer. The poor general state of the patient made it impossible to start any anti-leukaemic treatment and the patient died two months after the diagnosis was made. A review of the literature shows that 62 cases of granulocytic sarcoma have been reported of which 22 were in the breast, 19 in the ovary, 13 in the cervix or the uterus, 6 in the vagina and 2 in the vulva. The cells seem to invade the blood and the bone marrow in all occasions by the time of diagnosis or at the most a few weeks later and cases of granulocytic solitary sarcoma are very rare. It blood has not been attacked it is difficult to make a histological diagnosis unless immunological marking and Giemsa staining is carried out together with Leder's reaction. The treatment should be similar to those used for acute myeloid leukaemia.
我们报告了一例66岁女性患者的病史,该患者患有宫颈粒细胞肉瘤,表现为子宫出血,起初被认为是间变性癌。患者的一般状况较差,无法开始任何抗白血病治疗,诊断后两个月患者死亡。文献回顾显示,已报道62例粒细胞肉瘤病例,其中22例发生在乳腺,19例发生在卵巢,13例发生在宫颈或子宫,6例发生在阴道,2例发生在外阴。在诊断时或最多几周后,所有病例的细胞似乎都会侵入血液和骨髓,粒细胞孤立性肉瘤病例非常罕见。如果血液未受侵袭,除非同时进行免疫标记、吉姆萨染色和莱德反应,否则很难做出组织学诊断。治疗应与用于急性髓性白血病的治疗方法相似。