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[胸膜粒细胞肉瘤。附1例病例报告及文献复习]

[Pleural granulocytic sarcoma. Apropos of a case and review of the literature].

作者信息

Vottero G, Devouassoux G, Lantuejoul S, Pison C, Brambilla E, Brambilla C

机构信息

Service de Pneumologie, Université Joseph-Fourier, Hôpital Albert-Michallon, Grenoble.

出版信息

Rev Mal Respir. 1998 Jun;15(3):300-2.

PMID:9677640
Abstract

The granulocytic sarcoma is a rare and extramedullary tumor, which is composed of granulocytic precursor cells. The diagnosis remains difficult. Infectious disease are often associated with leukemic processes. Combination of clinical, radiological and pathological findings are useful for diagnosis. On gross examination, the tumor appears green. The detection of myeloperoxidases and the presence of immature eosinophils can help histological analysis. Granulocytic sarcoma occurs before or during an acute leukemia. It is treated like an acute leukemia. Prognostic is greatly improved by early diagnosis and treatment. The lack of cytogenetic abnormalities is associated with a prolonged survival. We describe a new case of rapidly growing pleural granulocytic sarcoma. The uncommon modifications of chromosome 5 long arm in this case could explain the immature eosinophil reaction in that tumor.

摘要

粒细胞肉瘤是一种罕见的髓外肿瘤,由粒细胞前体细胞组成。诊断仍然困难。传染病常与白血病过程相关。临床、放射学和病理学检查结果相结合有助于诊断。大体检查时,肿瘤呈绿色。髓过氧化物酶的检测和未成熟嗜酸性粒细胞的存在有助于组织学分析。粒细胞肉瘤发生于急性白血病之前或期间。其治疗方式与急性白血病相同。早期诊断和治疗可大大改善预后。缺乏细胞遗传学异常与生存期延长相关。我们描述了一例快速生长的胸膜粒细胞肉瘤新病例。该病例中5号染色体长臂的罕见改变可能解释了该肿瘤中的未成熟嗜酸性粒细胞反应。

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