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影响雪崩掩埋后存活的因素——一项随机前瞻性猪模型初步研究。

Factors affecting survival from avalanche burial--a randomised prospective porcine pilot study.

机构信息

Department of Anesthesiology and Critical Care Medicine, Innsbruck Medical University, Anichstraße 35, 6020 Innsbruck, Austria.

出版信息

Resuscitation. 2013 Feb;84(2):239-43. doi: 10.1016/j.resuscitation.2012.06.019. Epub 2012 Jul 6.

Abstract

BACKGROUND AND AIM

The majority of avalanche victims who sustain complete burial die within 35min due to asphyxia and injuries. After 35min, survival is possible only in the presence of a patent airway, and an accompanying air pocket around the face may improve survival. At this stage hypothermia is assumed to be an important factor for survival because rapid cooling decreases oxygen consumption; if deep hypothermia develops before cardiac arrest, hypothermia may be protective and prolong the time that cardiac arrest can be survived. The aim of the study was to investigate the combined effects of hypoxia, hypercapnia and hypothermia in a porcine model of avalanche burial.

METHODS

Eight piglets were anaesthetised, intubated and buried under snow, randomly assigned to an air pocket (n=5) or ambient air (n=3) group.

RESULTS

Mean cooling rates in the first 10min of burial were -19.7±4.7°Ch(-1) in the air pocket group and -13.0±4.4°Ch(-1) in the ambient air group (P=0.095); overall cooling rates between baseline and asystole were -4.7±1.4°Ch(-1) and -4.6±0.2°Ch(-1) (P=0.855), respectively. In the air pocket group cardiac output (P=0.002), arterial oxygen partial pressure (P=0.001), arterial pH (P=0.002) and time to asystole (P=0.025) were lower, while arterial carbon dioxide partial pressure (P=0.007) and serum potassium (P=0.042) were higher compared to the ambient air group.

CONCLUSION

Our results demonstrate that hypothermia may develop in the early phase of avalanche burial and severe asphyxia may occur even in the presence of an air pocket.

摘要

背景与目的

大多数完全被埋的雪崩受害者会在 35 分钟内因窒息和损伤而死亡。35 分钟后,只有在气道畅通的情况下才能存活,而面部周围伴随的气袋可能会提高存活率。在这个阶段,低温被认为是存活的一个重要因素,因为快速降温会降低耗氧量;如果在心脏骤停前出现深度低温,低温可能具有保护作用,并延长心脏骤停可以存活的时间。本研究的目的是研究缺氧、高碳酸血症和低温在雪崩埋置猪模型中的综合影响。

方法

8 头小猪接受麻醉、插管并被埋在雪中,随机分为气袋(n=5)或环境空气(n=3)组。

结果

在掩埋的前 10 分钟内,气袋组的平均降温率为-19.7±4.7°C/h,环境空气组为-13.0±4.4°C/h(P=0.095);从基线到心搏停止的整体降温率分别为-4.7±1.4°C/h 和-4.6±0.2°C/h(P=0.855)。在气袋组中,心输出量(P=0.002)、动脉血氧分压(P=0.001)、动脉 pH 值(P=0.002)和发生心搏停止的时间(P=0.025)均较低,而动脉二氧化碳分压(P=0.007)和血清钾(P=0.042)均较高。

结论

我们的结果表明,低温可能在雪崩埋置的早期阶段发展,即使存在气袋,也可能发生严重的窒息。

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