聚合物核酸载体：当前问题与新型设计方法。
Polymeric nucleic acid carriers: current issues and novel design approaches.
机构信息
Department of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, College of Pharmacy, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do 420-743, Republic of Korea.
出版信息
J Control Release. 2012 Dec 28;164(3):256-64. doi: 10.1016/j.jconrel.2012.06.036. Epub 2012 Jul 4.
Abstract
To deliver nucleic acids including plasmid DNA (pDNA) and short interfering RNA (siRNA), polymeric gene carriers equipped with various functionalities have been extensively investigated. The functionalities of these polymeric vectors have been designed to overcome various extracellular and intracellular hurdles that nucleic acids and their carriers encounter during their journey from injection site to intracellular target site. This review briefly introduces known extracellular and intracellular issues of nucleic acid delivery and their solution strategies. We examine significant yet overlooked factors affecting nucleic acid delivery (e.g., microenvironmental pH, polymer/siRNA complexation, and pharmaceutical formulation) and highlight our reported approaches to solve these problems.
摘要
为了递送包括质粒 DNA（pDNA）和小干扰 RNA（siRNA）在内的核酸，研究人员广泛探索了具有各种功能的聚合基因载体。这些聚合载体的功能设计旨在克服核酸及其载体在从注射部位到细胞内靶部位的过程中遇到的各种细胞外和细胞内障碍。本文简要介绍了核酸递送过程中已知的细胞外和细胞内问题及其解决方案策略。我们还考察了影响核酸递送的重要但被忽视的因素（例如微环境 pH 值、聚合物/siRNA 复合物形成和药物制剂），并重点介绍了我们为解决这些问题而提出的方法。
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