Takechi T, Kawamura M, Nakagawa H, Inatsuki S, Akiyama K, Yano M, Sumiyoshi Y, Mandai K, Moriwaki S, Kataoka M
Department of Radiology, National Hospital Shikoku Cancer Center.
Nihon Gan Chiryo Gakkai Shi. 1990 Nov 20;25(11):2724-7.
The treatment with hyperthermia in combination with radiation and intravesical pirarubicin (THP-ADM) was preliminary investigated in 5 patients with urinary bladder carcinoma in situ. Following intravesical administration of 30 mg THP-ADM, external irradiation of 3.0 Gy was delivered to the urinary bladder. Immediately then, hyperthermia using Thermotron RF-8 was performed for 50 min (intravesical temperature: 42-43 degrees C for 35 min). After five courses of the treatment, complete response has been maintained for 6, 8, and 9 months in 3 patients. However, in a patient with complete response, urinary cytology became positive in the 6th month after the treatment. In the remaining patient treatment was interrupted after only 3 courses due to urinary irritation, urinary cytology didn't become negative. The side effects of the combined treatment were limited to the transient symptoms of bladder irritation in all patients and thermal burn in 2 patients. These preliminary results suggest that this combined treatment may represent an effective conservative therapy for patients with urinary bladder carcinoma in situ.
对5例原位膀胱癌患者初步研究了热疗联合放疗及膀胱内灌注吡柔比星（THP - ADM）的治疗方法。膀胱内灌注30 mg THP - ADM后，对膀胱进行3.0 Gy的外照射。随后立即使用Thermotron RF - 8进行50分钟的热疗（膀胱内温度：42 - 43摄氏度，持续35分钟）。经过五个疗程的治疗，3例患者分别维持完全缓解6个月、8个月和9个月。然而，1例达到完全缓解的患者在治疗后第6个月尿细胞学检查转为阳性。其余1例患者仅进行3个疗程后因膀胱刺激症状而中断治疗，尿细胞学检查未转阴。联合治疗的副作用在所有患者中仅限于短暂的膀胱刺激症状，2例患者出现热灼伤。这些初步结果表明，这种联合治疗可能是原位膀胱癌患者一种有效的保守治疗方法。
