Baylor College of Medicine, Houston, TX, USA.
J Neuropsychiatry Clin Neurosci. 2012 Spring;24(2):208-14. doi: 10.1176/appi.neuropsych.11030077.
Stereotypies are frequently reported in frontotemporal dementia. Their pathophysiology and optimal treatment are largely unexplored. The author reports seven cases of marked stereotype in patients with probable frontotemporal dementia who were treated with tetrabenazine, a monoamine inhibitor. All patients had near-complete resolution of stereotypy. Six patients stopped tetrabenazine at some point, with return of their stereotype within 24 hours, which again improved in the four who restarted therapy. Efficacy has not waned over time. Tetrabenazine dramatically improved stereotypies in patients with dementia. This observation could increase understanding of this interesting phenotype.
刻板行为在额颞叶痴呆中经常被报道。其病理生理学和最佳治疗方法在很大程度上尚未被探索。作者报告了七例可能患有额颞叶痴呆的患者在使用单胺抑制剂四苯嗪治疗后出现明显刻板行为的病例。所有患者的刻板行为都几乎完全缓解。六名患者在某个时间点停止了四苯嗪治疗，24 小时内刻板行为又出现了，其中四人重新开始治疗后又得到了改善。随着时间的推移，疗效并未减弱。四苯嗪显著改善了痴呆患者的刻板行为。这一观察结果可以增加对这种有趣表型的理解。
