Department of Gastroenterology and Hepatology, Academic Medical Centre, University of Amsterdam, Amsterdam.
J Clin Gastroenterol. 2012 Aug;46(7):533-44. doi: 10.1097/MCG.0b013e31825692ce.
The prevalence of obesity is rising progressively, even among older age groups. By the year 2030 to 2035 over 20% of the adult US population and over 25% of the Europeans will be aged 65 years or older. The predicted prevalence of obesity in Americans, 60 years and older was 37% in 2010. The predicted prevalence of obesity in Europe in 2015 varies between 20% and 30% dependent on the model used. This means 20.9 million obese 60 years or older people in the United States in 2010 and 32 million obese elders in 2015 in EU. Although cutoff values of body mass index, waist circumference, and percentages of fat mass have not been defined for the elderly, it is clear from several meta-analyses that mortality and morbidity associated with overweight and obesity only increases at a body mass index >30 kg/m(2). Thus, treatment should only be offered to patients who are obese rather than overweight and who have functional impairments, metabolic complications, or obesity-related diseases, that can benefit from weight loss. The weight loss therapy should minimize muscle and bone loss and vigilance as regards the development of sarcopenic obesity--a combination of an unhealthy excess of body fat with a detrimental loss of muscle and fat-free mass including bone--is important. Lifestyle intervention should be the first step and consists of a diet with a 500 kcal energy deficit and an adequate intake of protein of high biological quality, together with calcium and vitamin D, behavioral therapy, and multicomponent exercise. Multicomponent exercise includes flexibility training, balance training, aerobic exercise, and resistance training. The adherence rate in most studies is around 75%. Knowledge of constraints and modulators of physical inactivity should be of help to engage the elderly in physical activity. The role of pharmacotherapy and bariatric surgery in the elderly is largely unknown as in most studies people aged 65 years and older were excluded.
肥胖的患病率正在逐步上升,甚至在老年人群中也是如此。到 2030 年至 2035 年,超过 20%的美国成年人口和超过 25%的欧洲人口将年满 65 岁。2010 年,美国 60 岁及以上人群肥胖的预测患病率为 37%。2015 年,欧洲不同模型预测的肥胖患病率在 20%至 30%之间。这意味着 2010 年美国有 2090 万 60 岁及以上的肥胖者,2015 年欧盟有 3200 万肥胖老人。虽然老年人的身体质量指数、腰围和体脂百分比的截止值尚未确定,但从几项荟萃分析来看,超重和肥胖相关的死亡率和发病率仅在身体质量指数>30kg/m(2)时才会增加。因此,只有那些肥胖而不是超重、有功能障碍、代谢并发症或肥胖相关疾病、可以从减肥中获益的患者才应该接受治疗。减肥治疗应尽量减少肌肉和骨量流失,并警惕肌少症性肥胖的发生——即不健康的体脂肪过多与肌肉和去脂体重(包括骨骼)的有害损失相结合。生活方式干预应是第一步,包括热量摄入减少 500 千卡的饮食,摄入高生物学质量的蛋白质,同时摄入钙和维生素 D,行为治疗和多成分运动。多成分运动包括柔韧性训练、平衡训练、有氧运动和阻力训练。大多数研究的依从率约为 75%。了解身体活动不足的限制因素和调节因素,有助于鼓励老年人参与身体活动。由于大多数研究都排除了 65 岁及以上的人群,因此,药物治疗和减肥手术在老年人中的作用在很大程度上仍不清楚。