Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
Reprod Sci. 2013 Mar;20(3):262-8. doi: 10.1177/1933719112451794. Epub 2012 Jul 5.
To determine the value of cervicovaginal interleukin (IL)-1β, IL-6, and IL-8 in predicting intra-amniotic infection and/or inflammation (IAI) in women with preterm labor.
Cervicovaginal fluid samples were collected for IL-1β, IL-6, and IL-8 measurements immediately before amniocentesis in 85 consecutive women with preterm labor. The IAI was defined as a positive amniotic fluid (AF) culture and/or an elevated AF IL-6 level (>2.6 ng/mL).
Receiver-operating characteristic curves demonstrated that cervicovaginal IL-6 and IL-8, but not IL-1β, predicted IAI. Cervicovaginal IL-6 had a significantly higher area under the curve (AUC) than cervicovaginal IL-8 (P = .009). However, the AUCs for the cervicovaginal IL-6 and AF white blood cell (WBC) were not significantly different.
Among measured cytokines, cervicovaginal IL-6 is the best marker to noninvasively identify IAI in women with preterm labor. Overall, this noninvasive parameter performed as well as AF WBC count for predicting IAI.
确定宫颈阴道白细胞介素（IL）-1β、IL-6 和 IL-8 在预测早产孕妇羊膜腔内感染和/或炎症（IAI）中的价值。
85 例连续早产孕妇在羊膜穿刺术前立即采集宫颈阴道液样本进行 IL-1β、IL-6 和 IL-8 测量。IAI 定义为羊水（AF）培养阳性和/或 AF IL-6 水平升高（>2.6ng/ml）。
受试者工作特征曲线表明，宫颈阴道 IL-6 和 IL-8 而非 IL-1β 可预测 IAI。宫颈阴道 IL-6 的曲线下面积（AUC）显著高于宫颈阴道 IL-8（P=0.009）。然而，宫颈阴道 IL-6 和 AF 白细胞（WBC）的 AUC 无显著差异。
在测量的细胞因子中，宫颈阴道 IL-6 是识别早产孕妇 IAI 的最佳非侵入性标志物。总体而言，该非侵入性参数在预测 IAI 方面与 AF WBC 计数表现相当。
