Mosny D S, Brito F, Bender H G
Department of Gynecology and Obstetrics, University of Düsseldorf, Frankfurt/Main, Federal Republic of Germany.
J Reprod Med. 1990 Nov;35(11):1005-7.
Atrophic disease of the vulvar epithelium can be treated with steroids, but carcinoma of the vulva cannot be influenced with any hormone therapy. Seventy-one vulvar specimens were tested for estrogen receptor (ER) content by means of immunohistochemistry. Slight ER staining was found in nonkeratinizing squamous epithelium in 17 of 22 cases. A weak ER reaction in the basal and parabasal layers was found in only 2 of 17 specimens of keratinizing squamous epithelium. However, no ER was found in any neoplastic tissue of the vulva or the adjacent stroma. The loss of ER in neoplastic cells could explain the clinical experience that antihormonal treatment of vulvar carcinomas produces no appreciable improvement.
外阴上皮萎缩性疾病可用类固醇治疗，但外阴癌无法通过任何激素疗法得到改善。采用免疫组织化学方法对71例外阴标本进行雌激素受体（ER）含量检测。22例非角化鳞状上皮中，17例有轻微ER染色。17例角化鳞状上皮标本中，仅2例在基底层和副基底层有微弱的ER反应。然而，在外阴任何肿瘤组织或邻近基质中均未发现ER。肿瘤细胞中ER的缺失可以解释抗激素治疗外阴癌未产生明显改善这一临床现象。
