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恶性周围神经鞘膜瘤：分化模式与免疫组化特征——一篇综述及我们的新发现

Malignant peripheral nerve sheath tumors: differentiation patterns and immunohistochemical features - a mini-review and our new findings.

作者信息

Guo Aitao, Liu Aijun, Wei Lixin, Song Xin

机构信息

Department of Pathology, the Chinese PLA General Hospital, Beijing 100853, China.

出版信息

J Cancer. 2012;3:303-9. doi: 10.7150/jca.4179. Epub 2012 Jul 4.

DOI:10.7150/jca.4179
PMID:22773934
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3390600/
Abstract

Malignant peripheral nerve sheath tumors (MPNST) represent a group of highly heterogeneous human malignancies often with multiple histological origins, divergent differentiation patterns, and diverse immunohistochemical presentations. The differential diagnosis of MPNST from other spindle cell neoplasms poses great challenges for pathologists. This report provides a mini-review of these unique features associated with MPNST and also presents the first cases of MPNST with six differentiation patterns.

摘要

恶性外周神经鞘瘤（MPNST）是一组高度异质性的人类恶性肿瘤，通常具有多种组织学起源、不同的分化模式和多样的免疫组化表现。将MPNST与其他梭形细胞瘤进行鉴别诊断对病理学家构成了巨大挑战。本报告对与MPNST相关的这些独特特征进行了简要综述，并首次报道了具有六种分化模式的MPNST病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1368/3390600/9bd81e2796a0/jcav03p0303g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1368/3390600/362c48106441/jcav03p0303g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1368/3390600/7b2d989d10d2/jcav03p0303g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1368/3390600/e76416fdac76/jcav03p0303g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1368/3390600/0d3febd167a0/jcav03p0303g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1368/3390600/9bd81e2796a0/jcav03p0303g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1368/3390600/362c48106441/jcav03p0303g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1368/3390600/7b2d989d10d2/jcav03p0303g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1368/3390600/e76416fdac76/jcav03p0303g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1368/3390600/0d3febd167a0/jcav03p0303g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1368/3390600/9bd81e2796a0/jcav03p0303g05.jpg

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Malignant peripheral nerve sheath tumours of the spine: clinical manifestations, classification, treatment, and prognostic factors.
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