Sawamura I, Hazama F, Kinoshita M
First Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan.
Jpn Circ J. 1990 Oct;54(10):1274-82. doi: 10.1253/jcj.54.10_1274.
In order to obtain fundamental information about the developmental mechanisms of myocardial fibrosis in chronic hypertension, the hearts of male spontaneously hypertensive rats of the stroke-prone strain (SHRSP) and Wistar rats of the Kyoto strain (WKY) were histologically and histometrically examined. Fibrosis was a prominent histological feature of the hearts in SHRSP. In consisted of focal, interstitial, and perivascular fibrosis. For histometrical analysis the percentage areas of interstitial and perivascular fibrosis were calculated by using a color image processor. The percentage area of myocardial fibrosis increased with advancing age in both SHRSP and WKY. However, it was significantly higher in SHRSP than in WKY at 18 and 30 weeks of age. In SHRSP perivascular fibrosis of small arteries had already appeared at 8 weeks of age, while perivascular fibrosis of arterioles and interstitial fibrosis developed later. It is supposed that perivascular as well as interstitial fibrosis is induced by the exudation of some growth factors due to an increased vascular permeability. On the other hand, the focal fibrosis observed in old SHRSP is suspected to occur as a result of injury in myocardium due to stenosis or occlusion of vessels.
为了获取慢性高血压中心肌纤维化发育机制的基础信息，对易卒中型雄性自发性高血压大鼠（SHRSP）和京都品系Wistar大鼠（WKY）的心脏进行了组织学和组织计量学检查。纤维化是SHRSP心脏突出的组织学特征。它由局灶性、间质和血管周围纤维化组成。对于组织计量学分析，使用彩色图像处理器计算间质和血管周围纤维化的面积百分比。在SHRSP和WKY中，心肌纤维化的面积百分比均随年龄增长而增加。然而，在18周和30周龄时，SHRSP中的该百分比显著高于WKY。在SHRSP中，小动脉的血管周围纤维化在8周龄时就已出现，而小动脉的血管周围纤维化和间质纤维化则在之后出现。据推测，血管周围和间质纤维化是由于血管通透性增加导致一些生长因子渗出而诱发的。另一方面，在老年SHRSP中观察到的局灶性纤维化被怀疑是由于血管狭窄或闭塞导致心肌损伤所致。
