Yamaguchi S
Third Department of Internal Medicine, Ehime University School of Medicine.
Nihon Shokakibyo Gakkai Zasshi. 1990 Nov;87(11):2457-65.
sIL2R in the sera of patients with viral liver diseases and primary biliary cirrhosis (PBC) were quantified with a solidphase enzyme immunoassay using two monoclonal antibodies against the receptor. As IL2 upregulated sIL2R release in vitro and in vivo, the serum levels of sIL2R might be a useful marker for T cell mediated immune responses. The sIL2R in patients with acute hepatitis, chronic hepatitis (CH) and PBC were significantly higher than those in control subjects. Serum sIL2R in patients with CH and PBC was capable of binding IL2 and did not affect IL2 depended immune responses of blastoid lymphocytes. These results suggest that IL2 production and sIL2R release increase significantly in patients with CH and PBC, and IL2 depended cytotoxic T cells may play a role of pathogenesis of CH and PBC.
采用两种抗该受体的单克隆抗体，通过固相酶免疫测定法定量检测病毒性肝病和原发性胆汁性肝硬化（PBC）患者血清中的可溶性白细胞介素2受体（sIL2R）。由于白细胞介素2（IL2）在体内外均上调sIL2R的释放，因此sIL2R的血清水平可能是T细胞介导的免疫反应的有用标志物。急性肝炎、慢性肝炎（CH）和PBC患者的sIL2R显著高于对照组。CH和PBC患者的血清sIL2R能够结合IL2，且不影响母细胞样淋巴细胞的IL2依赖性免疫反应。这些结果表明，CH和PBC患者的IL2产生和sIL2R释放显著增加，且IL2依赖性细胞毒性T细胞可能在CH和PBC的发病机制中起作用。
