Tyndyk M L, Popovich I G, Anikin I V, Egormin P A, Iurova M N, Zabezhinskiĭ M A, Anisimov V N
Vopr Onkol. 2012;58(2):243-7.
10 months old mice receiving SSH&H with daily food increased the lifespan in comparison to the control group. The maximal lifespan was increased by 1,6 months. For the long-living 10% group the mean lifespan increased by 8,7% compared to the control group (p<0,05). The mammary gland neoplasia rate was the same in both groups. The mean latent tumor development period duration, number and size of the tumors were also similar. There was a tendency to lower lung metastases rate in the experimental group. The cumulative neoplastic frequency curve for the experimental group was shifted to the right in comparison to the control group curve giving evidence to the inhibitory effect of SSH&H on the neoplastic rate in transgenic mice with HER-2/neu mutation.
与对照组相比，每日喂食SSH&H的10月龄小鼠寿命延长。最大寿命延长了1.6个月。对于长寿的10%组，平均寿命比对照组增加了8.7%（p<0.05）。两组的乳腺肿瘤发生率相同。肿瘤的平均潜伏发展期持续时间、数量和大小也相似。实验组的肺转移率有降低的趋势。与对照组曲线相比，实验组的累积肿瘤发生频率曲线向右移动，这证明了SSH&H对具有HER-2/neu突变的转基因小鼠肿瘤发生率有抑制作用。
