评估印度南部一家三级护理医院中 HIV/AIDS 患者的眼部表现和失明情况。

Evaluation of ocular manifestations and blindness in HIV/AIDS patients in a tertiary care hospital in South India.

机构信息

Nayana Superspecialty Eye Hospital and Research Center, Davangere, Karnataka, India.

出版信息

Ocul Immunol Inflamm. 2012 Oct;20(5):336-41. doi: 10.3109/09273948.2012.699133. Epub 2012 Jul 9.

DOI:10.3109/09273948.2012.699133

PMID:22775065

Abstract

PURPOSE

To report the prevalence of ocular manifestations in patients with HIV/AIDS and their correlation with the clinical stage of disease as well as the CD4 cell count.

METHODS

100 HIV-positive patients, who presented to a tertiary care hospital, were included. The WHO clinical staging of HIV/AIDS, CD4 count, duration of disease, and presence and type of ocular manifestations were noted.

RESULTS

Overall, 46 patients (46%) had ocular manifestations related to HIV/AIDS. The most common manifestations were HIV retinopathy (12%) and cytomegalovirus (CMV) retinitis (7%). The prevalence of ocular manifestations correlated significantly with the WHO clinical stages 3 and 4 of HIV/AIDS (p = .001) and with low CD4 count (p = .001).

CONCLUSIONS

CD4 cell counts and WHO clinical stage of HIV disease are important predictors for the occurrence of ocular morbidity in HIV-positive individuals. Routine comprehensive ophthalmic screening and appropriate initiation of therapy in these patients can potentially decrease ocular morbidity.

摘要

目的

报告 HIV/AIDS 患者眼部表现的患病率及其与疾病临床分期和 CD4 细胞计数的相关性。

方法

纳入 100 例在三级医院就诊的 HIV 阳性患者。记录世界卫生组织（WHO）HIV/AIDS 临床分期、CD4 计数、疾病持续时间以及眼部表现的存在和类型。

结果

共有 46 例（46%）患者出现与 HIV/AIDS 相关的眼部表现。最常见的表现是 HIV 视网膜病变（12%）和巨细胞病毒（CMV）视网膜炎（7%）。眼部表现的患病率与 HIV/AIDS 的 WHO 临床分期 3 期和 4 期显著相关（p =.001），与低 CD4 计数相关（p =.001）。