Nayana Superspecialty Eye Hospital and Research Center, Davangere, Karnataka, India.
Ocul Immunol Inflamm. 2012 Oct;20(5):336-41. doi: 10.3109/09273948.2012.699133. Epub 2012 Jul 9.
To report the prevalence of ocular manifestations in patients with HIV/AIDS and their correlation with the clinical stage of disease as well as the CD4 cell count.
100 HIV-positive patients, who presented to a tertiary care hospital, were included. The WHO clinical staging of HIV/AIDS, CD4 count, duration of disease, and presence and type of ocular manifestations were noted.
Overall, 46 patients (46%) had ocular manifestations related to HIV/AIDS. The most common manifestations were HIV retinopathy (12%) and cytomegalovirus (CMV) retinitis (7%). The prevalence of ocular manifestations correlated significantly with the WHO clinical stages 3 and 4 of HIV/AIDS (p = .001) and with low CD4 count (p = .001).
CD4 cell counts and WHO clinical stage of HIV disease are important predictors for the occurrence of ocular morbidity in HIV-positive individuals. Routine comprehensive ophthalmic screening and appropriate initiation of therapy in these patients can potentially decrease ocular morbidity.
报告 HIV/AIDS 患者眼部表现的患病率及其与疾病临床分期和 CD4 细胞计数的相关性。
纳入 100 例在三级医院就诊的 HIV 阳性患者。记录世界卫生组织（WHO）HIV/AIDS 临床分期、CD4 计数、疾病持续时间以及眼部表现的存在和类型。
共有 46 例（46%）患者出现与 HIV/AIDS 相关的眼部表现。最常见的表现是 HIV 视网膜病变（12%）和巨细胞病毒（CMV）视网膜炎（7%）。眼部表现的患病率与 HIV/AIDS 的 WHO 临床分期 3 期和 4 期显著相关（p =.001），与低 CD4 计数相关（p =.001）。
CD4 细胞计数和 HIV 疾病的 WHO 临床分期是 HIV 阳性个体发生眼部发病率的重要预测因素。对这些患者进行常规全面眼科筛查和适当的治疗可能会降低眼部发病率。
