高效抗逆转录病毒疗法七年对HIV感染患者眼科治疗的影响。

Seven years of HAART impact on ophthalmic management of HIV-infected patients.

作者信息

Kahraman Günal, Krepler Katharina, Franz Carmen, Ries Eva, Maar Noemi, Wedrich Andreas, Rieger Armin, Dejaco-Ruhswurm Irene

机构信息

Department of Ophthalmology, Medical University of Vienna, Austria.

出版信息

Ocul Immunol Inflamm. 2005 Apr-Jun;13(2-3):213-8. doi: 10.1080/09273940490912443.

DOI:10.1080/09273940490912443

PMID:16019681

Abstract

PURPOSE

The widespread use of highly active antiretroviral therapy (HAART) has changed the clinical picture of HIV-associated eye disease. We evaluated the incidence of ocular manifestations of HIV infection since the introduction of HAART.

METHODS

Between January 1996 and December 2002, we examined 539 HIV-infected patients in our hospital. Follow-up of the patients was performed in case of ophthalmologic symptoms, regardless of current immunologic status, or for screening.

RESULTS

A total of 217 patients (40.3%) had HIV-associated eye disease. Of these patients, 42.0% had no eye symptoms. Fifty-eight (10.8%) of the 539 patients had cytomegalovirus (CMV) retinitis, most of whom had CMV retinitis before receiving HAART. Four patients developed immune-recovery uveitis. A total of 145 patients (26.9%) had HIV-related microangiopathy and 96 (17.8%) had dry-eye syndrome.

CONCLUSION

The introduction of HAART had a major impact on the medical history of patients with HIV-related eye disease with improved survival time and decreased morbidity.

摘要

目的

高效抗逆转录病毒疗法（HAART）的广泛应用改变了HIV相关眼病的临床状况。我们评估了自引入HAART以来HIV感染眼部表现的发生率。

方法

1996年1月至2002年12月期间，我们对我院539例HIV感染患者进行了检查。无论患者当前的免疫状态如何，出现眼科症状时或为进行筛查时均对其进行随访。

结果

共有217例患者（40.3%）患有HIV相关眼病。在这些患者中，42.0%没有眼部症状。539例患者中有58例（10.8%）患有巨细胞病毒（CMV）视网膜炎，其中大多数患者在接受HAART之前就已患有CMV视网膜炎。4例患者发生了免疫重建葡萄膜炎。共有145例患者（26.9%）患有HIV相关微血管病变，96例（17.8%）患有干眼症。