在使用 GnRH 激动剂或 GnRH 拮抗剂进行控制性卵巢过度刺激的女性中，卵泡液中 IGF-I、IGF-II、IGFBP-3、VEGF、AMH 和抑制素-B 的浓度。
Follicular fluid concentrations of IGF-I, IGF-II, IGFBP-3, VEGF, AMH, and inhibin-B in women undergoing controlled ovarian hyperstimulation using GnRH agonist or GnRH antagonist.
机构信息
Ankara University School of Medicine, Department of Obstetrics and Gynecology, 06100 Ankara, Turkey.
出版信息
Eur J Obstet Gynecol Reprod Biol. 2012 Oct;164(2):167-71. doi: 10.1016/j.ejogrb.2012.06.010. Epub 2012 Jul 7.
OBJECTIVE
To compare follicular fluid concentrations of IGF-I, IGF-II, IGFBP-3, inhibin-B, VEGF, and AMH in women undergoing controlled ovarian hyperstimulation with a long-luteal GnRH agonist protocol or multiple-dose GnRH antagonist protocol.
STUDY DESIGN
A total of 80 cycles were included; long-luteal GnRH agonist group (n=40) and multiple dose GnRH antagonist group (n=40). All follicular fluid samples were obtained from mature follicles during oocyte retrieval. IGF-I and IGFBP-3 concentrations were measured by immunoradiometric assay. IGF-II, VEGF, AMH, and inhibin-B concentrations were measured by enzyme-linked immunosorbent assay.
RESULTS
There were no significant differences in the concentrations of the studied follicular fluid markers, cycle parameters, and treatment outcomes between GnRH agonist and GnRH antagonist protocols.
CONCLUSIONS
The long-luteal GnRH agonist protocol and multiple-dose GnRH antagonist protocol seem to have similar effects on the follicular microenvironment in women undergoing controlled ovarian hyperstimulation.
目的
比较接受长黄体期 GnRH 激动剂方案或多剂量 GnRH 拮抗剂方案控制性卵巢刺激的女性的卵泡液中 IGF-I、IGF-II、IGFBP-3、抑制素-B、VEGF 和 AMH 的浓度。
研究设计
共纳入 80 个周期；长黄体期 GnRH 激动剂组（n=40）和多剂量 GnRH 拮抗剂组（n=40）。所有卵泡液样本均在卵母细胞回收时从成熟卵泡中获得。IGF-I 和 IGFBP-3 浓度采用免疫放射分析测定。IGF-II、VEGF、AMH 和抑制素-B 浓度采用酶联免疫吸附试验测定。
结果
GnRH 激动剂和 GnRH 拮抗剂方案之间的研究卵泡液标志物浓度、周期参数和治疗结局无显著差异。
结论
在接受控制性卵巢刺激的女性中，长黄体期 GnRH 激动剂方案和多剂量 GnRH 拮抗剂方案似乎对卵泡微环境具有相似的影响。
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