埃及国家癌症研究所就诊的癌症患者中骨髓坏死的患病率
Prevalence of bone marrow necrosis in Egyptian cancer patients referring to the National Cancer Institute.
作者信息
Elgamal Basma M, Rashed Reham A, Raslan Heba N
机构信息
Hematology Unit, Clinical Pathology Department, National Cancer Institute, Cairo University, Egypt.
出版信息
J Egypt Natl Canc Inst. 2011 Sep;23(3):95-9. doi: 10.1016/j.jnci.2011.09.007. Epub 2011 Oct 21.
BACKGROUND
Bone marrow necrosis is a relatively rare entity which has been associated with a poor prognosis. It is most commonly found in patients with neoplastic disorders and severe infections.
METHODS
The study comprised examination of 5043 bone marrow biopsy specimens performed at the National Cancer Institute, Cairo University, over 7 years period (March 2004-March 2011). It included 5 years retrospective (2867 archived samples) and 2 years prospective (2176 samples).
RESULTS
Bone marrow necrosis was diagnosed in fifteen out of 5043 examined specimens with a percentage of 0.3% and ranged from mild to massive according to semiquantitative estimation. Prognosis of all patients was poor with survival not exceeding 6 months from the date of marrow necrosis diagnosis.
CONCLUSION
In Egyptian patients, bone marrow necrosis in association with malignancy is a rare disorder which is accompanied by a poor outcome.
背景
骨髓坏死是一种相对罕见的疾病，其预后较差。它最常见于患有肿瘤性疾病和严重感染的患者。
方法
该研究包括对开罗大学国家癌症研究所7年期间（2004年3月至2011年3月）进行的5043例骨髓活检标本的检查。其中包括5年回顾性研究（2867份存档样本）和2年前瞻性研究（2176份样本）。
结果
在5043例检查标本中，有15例诊断为骨髓坏死，占比0.3%，根据半定量评估，范围从轻度到重度。所有患者的预后都很差，自骨髓坏死诊断之日起存活时间不超过6个月。
结论
在埃及患者中，与恶性肿瘤相关的骨髓坏死是一种罕见疾病，预后不良。
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