Yesodharan Jyotsna, Kuruvilla Shalini, Parameswaran Kavitha Kanjirakkad, Lilly Madhavan
Malabar Institute of Medical Sciences Ltd., Calicut, Kerala, India.
Transl Gastroenterol Hepatol. 2016 Mar 16;1:6. doi: 10.21037/tgh.2016.03.09. eCollection 2016.
Cancer related microangiopathic hemolytic anemia (MAHA) and bone marrow necrosis (BMN) are two rare and distinct clinicopathological entities reported in patients with disseminated malignancy. When they emerge as initial findings in a previously undetected case of malignancy, the diagnosis is often missed resulting in inappropriate management. We report the extremely rare association of cancer related MAHA and BMN as the first presentation of unsuspected disseminated gastric carcinoma in a 63 years old male. Early institution of chemotherapy is the only effective option for both these conditions, though with little improvement in outcome. This emphasises the need for increased awareness of such presentations in advanced malignancies.
癌症相关的微血管病性溶血性贫血(MAHA)和骨髓坏死(BMN)是在播散性恶性肿瘤患者中报道的两种罕见且不同的临床病理实体。当它们在先前未被发现的恶性肿瘤病例中作为初始表现出现时,诊断常常被漏诊,导致处理不当。我们报告了一名63岁男性患者中,癌症相关的MAHA和BMN极为罕见地同时出现,作为未被怀疑的播散性胃癌的首发表现。对于这两种情况,早期进行化疗是唯一有效的选择,尽管预后改善甚微。这强调了提高对晚期恶性肿瘤中此类表现认识的必要性。