University of Minnesota Amplatz Children's Hospital, Minneapolis, MN 55454, USA.
Curr Diab Rep. 2012 Oct;12(5):580-6. doi: 10.1007/s11892-012-0296-1.
For patients with severe chronic pancreatitis refractory to medical interventions, total pancreatectomy can be considered to relieve the root cause of pain. The goal of a simultaneous islet autotransplant is to prevent or minimize the otherwise inevitable surgical diabetes. Islet autotransplant can successfully preserve some endogenous islet function in the majority of recipients, which mediates protection against brittle diabetes. Most maintain reasonably good glycemic control, while 30 %-40 % successfully discontinue insulin therapy. With islet autotransplants reaching a wider clinical audience, refinements in islet isolation techniques and strategies to protect islet grafts post-transplant may further improve the success of this procedure.
对于药物治疗无效的重症慢性胰腺炎患者，可以考虑行全胰腺切除术以解除疼痛根源。胰岛自体移植的目的是预防或最小化不可避免的手术性糖尿病。胰岛自体移植可以使大多数受者成功保留部分内源性胰岛功能，从而对脆性糖尿病起到保护作用。大多数受者可较好地控制血糖，其中 30%-40%的受者成功停止胰岛素治疗。随着胰岛自体移植在更广泛的临床人群中开展，胰岛分离技术的改进和移植后胰岛移植物保护策略可能会进一步提高该手术的成功率。
