弗里德尔-克拉夫茨型反应与脲和硫脲。

Friedel-Crafts-type reactions with ureas and thioureas.

机构信息

Department of Chemistry and Biochemistry, Northern Illinois University, DeKalb, Illinois 60115, USA.

出版信息

Chem Commun (Camb). 2012 Aug 21;48(65):8141-3. doi: 10.1039/c2cc34062c. Epub 2012 Jul 10.

Abstract

Despite the relatively low reactivities of urea and thiourea functional groups towards nucleophilic attack, we have found conditions in which they are useful substrates in Friedel-Crafts reactions. The Brønsted superacid, triflic acid, promotes these reactions and a mechanism is proposed involving dicationic, superelectrophilic intermediates.

摘要

尽管尿素和硫脲官能团的反应活性相对较低，但我们已经找到了在这些条件下它们在傅克反应中可用作底物的条件。布朗斯台德超强酸三氟甲磺酸促进了这些反应，并提出了一种涉及二阳离子、超亲电中间体的反应机制。