Lewandowski K, Psuja P, Zozulińska M, Turowiecka Z, Zawilska K
Kliniki Hematologii, AM im. K. Marcinkowskiego w Poznaniu.
Pol Arch Med Wewn. 1990 Aug;84(2):79-85.
The study was carried out of 53 patients with acute myocardial infarction receiving no anticoagulant treatment. Changes were traced in certain indices of the blood clotting system and fibrinolysis in plasma in the first 14 days of the disease, with particular attention given to patients in whom during the hospitalization signs of deep vein thrombosis in the lower extremities appeared or a positive result was obtained of the test with 125I-fibrinogen. In a group of 9 patients with deep vein thrombosis developing during the observation, on the first day of myocardial infarction shortening of the kaolin-cephalin clotting time and considerable rise of the level of fibrinogen-fibrin (FDP) degradation products were noted in serum, and on the 14th day raised fibrinogen level and reduced exogenous fibrinolytic activity of the plasma were noted. Increased level of fibrinogen and FDP and exogenous and endogenous plasma fibrinolytic activity observed on the 7th day of the disease were not related to the development of thrombotic complications. The thrombin clotting time, platelet count, factor X level, protein C concentration and antithrombin III activity in the plasma were not significantly changed during myocardial infarction. The obtained results suggest a limited usefulness of the basic tests of the clotting and fibrinolytic systems for early diagnosis of deep vein thrombosis in acute myocardial infarction.
对53例未接受抗凝治疗的急性心肌梗死患者进行了研究。在疾病的前14天追踪血浆中凝血系统和纤维蛋白溶解的某些指标变化，特别关注住院期间出现下肢深静脉血栓形成迹象或125I - 纤维蛋白原试验呈阳性结果的患者。在观察期间发生深静脉血栓形成的9例患者组中，在心肌梗死第一天血清中高岭土 - 脑磷脂凝血时间缩短，纤维蛋白原 - 纤维蛋白（FDP）降解产物水平显著升高，在第14天观察到血浆纤维蛋白原水平升高，外源性纤维蛋白溶解活性降低。在疾病第7天观察到的纤维蛋白原和FDP水平升高以及血浆外源性和内源性纤维蛋白溶解活性与血栓形成并发症的发生无关。心肌梗死期间血浆中的凝血酶凝血时间、血小板计数、X因子水平、蛋白C浓度和抗凝血酶III活性无明显变化。所得结果表明，凝血和纤维蛋白溶解系统的基本检测对急性心肌梗死中深静脉血栓形成的早期诊断作用有限。
