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起源于小脑的外生性胶质母细胞瘤:病例报告及文献综述

Exophytic glioblastoma arising from the cerebellum: case report and critical review of the literature.

作者信息

Linsenmann Thomas, Monoranu Camelia Maria, Westermaier Thomas, Varallyay Csanad, Ernestus Ralf-Ingo, Vince Giles Hamilton

机构信息

Department of Neurosurgery, University of Wuerzburg, Wuerzburg, Bavaria, Germany.

出版信息

J Neurol Surg A Cent Eur Neurosurg. 2013 Jul;74(4):262-4. doi: 10.1055/s-0032-1304218. Epub 2012 Jul 9.

Abstract

Exophytic glioblastoma arising from the cerebellar tonsil is an extremely rare variant within the possible anatomical presentations of the glioblastoma multiforme (GBM). We report the case of a 55-year-old woman who presented with a tumor located at the cranio-cervical junction with compression of the medulla oblongata and consecutive hydrocephalus. Due to the radiological presentation, the first tentative diagnosis was a meningioma. The tumor was microsurgically removed. Histopathological examination of the tumor revealed a GBM WHO IV. The patient underwent a postoperative percutaneous radiotherapy and concomitant chemotherapy with temozolomide. GBM should be also considered in the differential diagnosis of cerebellar tumors.

摘要

起源于小脑扁桃体的外生性胶质母细胞瘤是多形性胶质母细胞瘤(GBM)可能的解剖学表现中极为罕见的一种变体。我们报告了一例55岁女性病例,该患者的肿瘤位于颅颈交界处,压迫延髓并导致继发性脑积水。由于影像学表现,最初的初步诊断为脑膜瘤。该肿瘤通过显微手术切除。肿瘤的组织病理学检查显示为WHO IV级胶质母细胞瘤。患者术后接受了经皮放射治疗并同时使用替莫唑胺进行化疗。在小脑肿瘤的鉴别诊断中也应考虑胶质母细胞瘤。

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