丹曲林预处理对绵羊中暑的影响。

Effect of dantrolene pretreatment on heat stroke in sheep.

作者信息

Tayeb O S, Marzouki Z M

机构信息

Department of Pharmacology, College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

出版信息

Pharmacol Res. 1990 Sep-Oct;22(5):565-72. doi: 10.1016/s1043-6618(05)80048-9.

DOI:10.1016/s1043-6618(05)80048-9

PMID:2277797

Abstract

Dantrolene is effective in the management of malignant hyperpyrexia. Due to the similarities of malignant hyperpyrexia and heat stroke, we have investigated the effect of dantrolene on heat stroke in sheep. Our study indicates that dantrolene pretreatment decreases the extent of heat stroke signs and some of the induced changes in enzymes and hormones. These results indicate that dantrolene may be a valuable drug in the prophylaxis against heat stroke attack in susceptible individuals.

摘要

丹曲林对恶性高热的治疗有效。鉴于恶性高热与中暑的相似性，我们研究了丹曲林对绵羊中暑的影响。我们的研究表明，丹曲林预处理可减轻中暑症状的严重程度以及一些酶和激素的诱导变化。这些结果表明，丹曲林可能是预防易感个体中暑发作的一种有价值的药物。