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Pirtobrutinib in relapsed or refractory B-cell malignancies (BRUIN): a phase 1/2 study.泊鲁替尼治疗复发或难治性 B 细胞恶性肿瘤（BRUIN）：一项 1/2 期研究。
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本文引用的文献

1
The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia.临床上有效的 BTK 抑制剂 PCI-32765 靶向慢性淋巴细胞白血病中 B 细胞受体和趋化因子控制的黏附和迁移。
Blood. 2012 Mar 15;119(11):2590-4. doi: 10.1182/blood-2011-11-390989. Epub 2012 Jan 25.
2
The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo.布鲁顿酪氨酸激酶抑制剂 PCI-32765 可阻止慢性淋巴细胞白血病细胞在体外和体内的存活和组织归巢。
Blood. 2012 Feb 2;119(5):1182-9. doi: 10.1182/blood-2011-10-386417. Epub 2011 Dec 16.
3
Biological effects and clinical significance of lenalidomide-induced tumour flare reaction in patients with chronic lymphocytic leukaemia: in vivo evidence of immune activation and antitumour response.来那度胺诱导的慢性淋巴细胞白血病肿瘤 flares 反应的生物学效应和临床意义：免疫激活和抗肿瘤反应的体内证据。
Br J Haematol. 2011 Nov;155(4):457-67. doi: 10.1111/j.1365-2141.2011.08882.x. Epub 2011 Oct 20.
4
The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia.磷酸肌醇 3-激酶 δ 抑制剂 CAL-101 抑制慢性淋巴细胞白血病中 B 细胞受体信号和趋化因子网络。
Blood. 2011 Sep 29;118(13):3603-12. doi: 10.1182/blood-2011-05-352492. Epub 2011 Jul 29.
5
Optimising the lymphoma response criteria in the era of targeted therapy.在靶向治疗时代优化淋巴瘤反应标准。
Lancet Oncol. 2011 Jul;12(7):616-7. doi: 10.1016/S1470-2045(11)70132-2. Epub 2011 Jun 12.
6
Tumor flare reaction associated with lenalidomide treatment in patients with chronic lymphocytic leukemia predicts clinical response.来那度胺治疗慢性淋巴细胞白血病患者相关的肿瘤 flares 反应可预测临床反应。
Cancer. 2011 May 15;117(10):2127-35. doi: 10.1002/cncr.25748. Epub 2010 Nov 29.
7
Phase II study of dasatinib in relapsed or refractory chronic lymphocytic leukemia.达沙替尼治疗复发或难治性慢性淋巴细胞白血病的 II 期研究。
Clin Cancer Res. 2011 May 1;17(9):2977-86. doi: 10.1158/1078-0432.CCR-10-2879. Epub 2011 Mar 14.
8
The treatment of recurrent/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) with everolimus results in clinical responses and mobilization of CLL cells into the circulation.依维莫司治疗复发性/难治性慢性淋巴细胞白血病/小淋巴细胞淋巴瘤（CLL）可产生临床缓解，并使 CLL 细胞动员到循环中。
Cancer. 2010 May 1;116(9):2201-7. doi: 10.1002/cncr.25005.
9
Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia.福他替尼二钠盐抑制 Syk 在非霍奇金淋巴瘤和慢性淋巴细胞白血病中具有显著的临床活性。
Blood. 2010 Apr 1;115(13):2578-85. doi: 10.1182/blood-2009-08-236471. Epub 2009 Nov 17.
10
Lenalidomide treatment promotes CD154 expression on CLL cells and enhances production of antibodies by normal B cells through a PI3-kinase-dependent pathway.来那度胺治疗可促进 CLL 细胞 CD154 的表达，并通过 PI3-激酶依赖途径增强正常 B 细胞产生抗体。
Blood. 2010 Apr 1;115(13):2619-29. doi: 10.1182/blood-2009-09-242438. Epub 2009 Nov 24.

Novel targeted agents and the need to refine clinical end points in chronic lymphocytic leukemia.

作者信息

Cheson Bruce D, Byrd John C, Rai Kanti R, Kay Neil E, O'Brien Susan M, Flinn Ian W, Wiestner Adrian, Kipps Thomas J

机构信息

Lombardi Comprehensive Cancer Center, Georgetown University Hospital, Washington, DC, USA.

出版信息

J Clin Oncol. 2012 Aug 10;30(23):2820-2. doi: 10.1200/JCO.2012.43.3748. Epub 2012 Jul 9.

DOI:10.1200/JCO.2012.43.3748
PMID:22778323
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3410400/
Abstract
摘要