Yu Haoyong, Li Ruixia, Zhang Lei, Chen Haibing, Bao Yuqian, Jia Weiping
School of Medicine, Shanghai Jiao Tong University, Shanghai 200233, China.
Exp Diabetes Res. 2012;2012:745189. doi: 10.1155/2012/745189. Epub 2012 Jun 12.
CA19-9 is a tumor-associated antigen. It is also a marker of pancreatic tissue damage that might be caused by diabetes. Long-term poor glycemic control may lead to pancreatic beta cell dysfunction which is reflected by elevated serum CA19-9 level. Intracellular cholesterol accumulation leads to islet dysfunction and impaired insulin secretion which provide a new lipotoxic model. This study firstly found total cholesterol was one of the independent contributors to CA19-9. Elevated serum CA19-9 level in diabetic patients may indicate further investigations of glycemic control, pancreatic beta cell function, and total cholesterol level.
CA19-9是一种肿瘤相关抗原。它也是可能由糖尿病引起的胰腺组织损伤的标志物。长期血糖控制不佳可能导致胰腺β细胞功能障碍，这表现为血清CA19-9水平升高。细胞内胆固醇蓄积导致胰岛功能障碍和胰岛素分泌受损，这提供了一种新的脂毒性模型。本研究首次发现总胆固醇是CA19-9的独立影响因素之一。糖尿病患者血清CA19-9水平升高可能提示需要进一步检查血糖控制情况、胰腺β细胞功能和总胆固醇水平。
