Ayala García Marco Antonio, González Yebra Beatriz, López Flores Andrea Liliana, Guaní Guerra Eduardo
Investigación, Hospital Regional de Alta Especialidad del Bajío, Blvd. Milenio No. 130, San Carlos/La Roncha, 37660 León, GTO, Mexico.
J Transplant. 2012;2012:842141. doi: 10.1155/2012/842141. Epub 2012 Jun 20.
The transplant of organs is one of the greatest therapeutic achievements of the twentieth century. In organ transplantation, the adaptive immunity is considered the main response exerted to the transplanted tissue, since the principal target of the immune response is the MHC (major histocompatibility complex) molecules expressed on the surface of donor cells. However, we should not forget that the innate and adaptive immunities are closely interrelated and should be viewed as complementary and cooperating. When a human transplant is performed, HLA (human leukocyte antigens) molecules from a donor are recognized by the recipient's immune system triggering an alloimmune response Matching of donor and recipient for MHC antigens has been shown to have a significant positive effect on graft acceptance. This paper will present MHC, the innate and adaptive immunities, and clinical HLA testing.
器官移植是二十世纪最伟大的治疗成就之一。在器官移植中,适应性免疫被认为是对移植组织产生的主要反应,因为免疫反应的主要靶点是供体细胞表面表达的MHC(主要组织相容性复合体)分子。然而,我们不应忘记,固有免疫和适应性免疫密切相关,应被视为互补和协同的。进行人体移植时,供体的HLA(人类白细胞抗原)分子会被受体的免疫系统识别,从而引发同种免疫反应。已证明供体和受体的MHC抗原匹配对移植物接受有显著的积极影响。本文将介绍MHC、固有免疫和适应性免疫以及临床HLA检测。