Gumkowska Olga, Kotyla Przemysław J, Kucharz Eugeniusz J
Oddział Chorób Wewnetrznych i Reumatologii SUM SPSK nr 7 GCM w Katowicach.
Pol Merkur Lekarski. 2012 May;32(191):318-22.
Systemic lupus erythematosus is a connective tissue disease of unknown origin and unpredictable course. At the moment there is no specific targeted treatment for the disease and corticosteroids are still main therapeutic option. Steroid use, however brings many side effects. Therefore searching for new treatment strategies is at the moment the main challenge for rheumatologists. The potential targets for the treatment include B and T cells co-stimulation molecules and various cytokines. In the paper potential targets for treatment of SLE have been reviewed with the special emphasis to the result of recently finished clinical trials in this indication.
系统性红斑狼疮是一种病因不明、病程不可预测的结缔组织疾病。目前尚无针对该疾病的特异性靶向治疗方法，糖皮质激素仍是主要的治疗选择。然而，使用糖皮质激素会带来许多副作用。因此，寻找新的治疗策略是目前风湿病学家面临的主要挑战。治疗的潜在靶点包括B细胞和T细胞共刺激分子以及各种细胞因子。本文综述了系统性红斑狼疮治疗的潜在靶点，并特别强调了该适应症近期完成的临床试验结果。
