Salako L A, Adio R A, Sowunmi A, Walker O
Department of Pharmacology and Therapeutics, University of Ibadan, Nigeria.
Trans R Soc Trop Med Hyg. 1990 Sep-Oct;84(5):641-3. doi: 10.1016/0035-9203(90)90131-w.
One hundred and eighteen patients with acute falciparum malaria were randomized into treatment with either intramuscular or oral sulfadoxine-pyrimethamine (Fansidar, Roche) and the results were compared with those from 68 patients treated in parallel with chloroquine. Parasitological cure rate was 97% with oral sulfadoxine-pyrimethamine, 95% with the injection, and only 63% with chloroquine. The time for the disappearance of parasitaemia in sensitive cases was the same with oral and intramuscular sulfadoxine-pyrimethamine and shorter than with chloroquine. Side effects occurred in only 3 of the patients treated with intramuscular sulfadoxine-pyrimethamine compared with 8 of those treated with the tablets and 13 of those treated with chloroquine. The results showed that intramuscular sulfadoxine-pyrimethamine is as effective as, and probably better tolerated than, the oral drug. Increasing failure of response to chloroquine in Nigeria was also demonstrated.
118例急性恶性疟患者被随机分为接受肌肉注射或口服磺胺多辛-乙胺嘧啶（Fansidar，罗氏公司）治疗两组，并将结果与68例接受氯喹平行治疗的患者进行比较。口服磺胺多辛-乙胺嘧啶的寄生虫学治愈率为97%，注射用药为95%，而氯喹仅为63%。在敏感病例中，口服和肌肉注射磺胺多辛-乙胺嘧啶使疟原虫血症消失的时间相同，且短于氯喹。肌肉注射磺胺多辛-乙胺嘧啶治疗的患者中仅3例出现副作用，相比之下，片剂治疗的患者有8例，氯喹治疗的患者有13例。结果表明，肌肉注射磺胺多辛-乙胺嘧啶与口服药物效果相同，且耐受性可能更好。同时也证实了在尼日利亚对氯喹耐药性增加的情况。
