透明质酸寡糖的自动化固相合成。
Automated solid-phase synthesis of hyaluronan oligosaccharides.
机构信息
Leiden Institute of Chemistry, Leiden University , P.O. Box 9502, 2300 RA Leiden, The Netherlands, and Ancora Pharmaceuticals , 1B Gill Street, Woburn, Massachusetts 01801, United States.
出版信息
Org Lett. 2012 Jul 20;14(14):3776-9. doi: 10.1021/ol301666n. Epub 2012 Jul 10.
Well-defined fragments of hyaluronic acid (HA) have been obtained through a fully automated solid-phase oligosaccharide synthesis. Disaccharide building blocks, featuring a disarmed glucuronic acid donor moiety and a di-tert-butylsilylidene-protected glucosamine part, were used in the rapid and efficient assembly of HA fragments up to the pentadecamer level, equipped with a conjugation-ready anomeric allyl function.
通过全自动固相寡糖合成，得到了结构明确的透明质酸（HA）片段。在快速高效的 HA 片段组装中，使用了二糖砌块，其特征是无保护的葡萄糖醛酸供体部分和叔丁基二甲基甲硅烷基保护的葡萄糖胺部分，可将 HA 片段组装至十五聚体水平，同时还带有可进行偶联的烯丙基端。
Zotero 插件