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透明质酸的化学修饰及其生物医学应用

Chemical Modification of Hyaluronan and Their Biomedical Applications.

作者信息

Hintze Vera, Schnabelrauch Matthias, Rother Sandra

机构信息

Institute of Materials Science, Max Bergmann Center of Biomaterials, Technische Universität Dresden, Dresden, Germany.

Biomaterials Department, INNOVENT e. V., Jena, Germany.

出版信息

Front Chem. 2022 Feb 11;10:830671. doi: 10.3389/fchem.2022.830671. eCollection 2022.

DOI:10.3389/fchem.2022.830671
PMID:35223772
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8873528/
Abstract

Hyaluronan, the extracellular matrix glycosaminoglycan, is an important structural component of many tissues playing a critical role in a variety of biological contexts. This makes hyaluronan, which can be biotechnologically produced in large scale, an attractive starting polymer for chemical modifications. This review provides a broad overview of different synthesis strategies used for modulating the biological as well as material properties of this polysaccharide. We discuss current advances and challenges of derivatization reactions targeting the primary and secondary hydroxyl groups or carboxylic acid groups and the -acetyl groups after deamidation. In addition, we give examples for approaches using hyaluronan as biomedical polymer matrix and consequences of chemical modifications on the interaction of hyaluronan with cells via receptor-mediated signaling. Collectively, hyaluronan derivatives play a significant role in biomedical research and applications indicating the great promise for future innovative therapies.

摘要

透明质酸是一种细胞外基质糖胺聚糖，是许多组织的重要结构成分，在多种生物学环境中发挥关键作用。这使得能够通过生物技术大规模生产的透明质酸成为化学修饰的有吸引力的起始聚合物。本综述广泛概述了用于调节这种多糖的生物学和材料特性的不同合成策略。我们讨论了针对伯羟基和仲羟基、羧酸基团以及脱酰胺后的乙酰基的衍生化反应的当前进展和挑战。此外，我们给出了使用透明质酸作为生物医学聚合物基质的方法示例，以及化学修饰对透明质酸通过受体介导的信号传导与细胞相互作用的影响。总的来说，透明质酸衍生物在生物医学研究和应用中发挥着重要作用，预示着未来创新疗法的巨大前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fa2/8873528/d7f1720c35eb/fchem-10-830671-g014.jpg
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