Ghanizadeh G, Babaei M, Naghii Mohammad Reza, Mofid M, Torkaman G, Hedayati M
1Environmental Health Group, Baqiyatallah University of Medical Sciences, Tehran, Islamic Republic of Iran.
Toxicol Ind Health. 2014 Apr;30(3):211-7. doi: 10.1177/0748233712452775. Epub 2012 Jul 10.
Evidence indicates that optimal nutrition plays a role in bone formation and maintenance. Besides major components of mineralization such as calcium, phosphorus, and vitamin D, other nutrients like boron and fluoride have beneficial role, too. In this study, 34 male Wistar rats were divided into five groups: control diet, fluoride, fluoride + boron, fluoride + calcium + vitamin D, and fluoride + boron + calcium + vitamin D. Boron equal to 1.23 mg, calcium and vitamin D equal to 210 mg + 55 IU and fluoride equal to 0.7 mg/rat/day was added to their drinking water for 8 weeks. Plasma blood samples and bones were collected. Findings are evidence that fluoride + boron intake revealed significant positive effects on bone mechanical properties and bone metabolic hormones. These findings suggest that combined intake of these two elements has beneficial effects on bone stiffness and breaking strength comparing to even calcium + vitamin D supplementation. This evidence dealing with health problems related to bone and skeletal system in humans should justify further investigation of the role of boron and fluoride with other elements in relation to bone.
有证据表明，最佳营养在骨骼形成和维持中发挥作用。除了矿化的主要成分如钙、磷和维生素D外，其他营养素如硼和氟也有有益作用。在本研究中，34只雄性Wistar大鼠被分为五组：对照饮食组、氟组、氟+硼组、氟+钙+维生素D组和氟+硼+钙+维生素D组。向它们的饮用水中添加相当于1.23毫克的硼、210毫克+55国际单位的钙和维生素D以及相当于0.7毫克/只/天的氟，持续8周。采集血浆样本和骨骼。研究结果证明，摄入氟+硼对骨骼力学性能和骨代谢激素有显著的积极影响。这些发现表明，与补充钙+维生素D相比，这两种元素的联合摄入对骨骼硬度和断裂强度有有益影响。这一涉及人类骨骼和骨骼系统健康问题的证据应证明进一步研究硼和氟与其他元素在骨骼方面的作用是合理的。
