大肠杆菌突变单链结合蛋白：遗传与生理学特性
Mutant single-strand binding protein of Escherichia coli: genetic and physiological characterization.
作者信息
Glassberg J, Meyer R R, Kornberg A
出版信息
J Bacteriol. 1979 Oct;140(1):14-9. doi: 10.1128/jb.140.1.14-19.1979.
Abstract
A mutation in the Escherichia coli gene for single-strand binding protein results in temperature-sensitive deoxyribonucleic acid replication (R. R. Meyer, J. Glassberg, and A. Kornberg, Proc. Natl. Acad. Sci. U.S.A. 76:1702-1705, 1979). The mutant (ssb-1) is also more sensitive to ultraviolet irradiation and about one-fifth as active in recombination. Single-strand binding protein is thus implicated in repair and recombination as well as in replication. The mutation in ssb is located between uvrA and melA at 90.8 min on the genetic map. The ssb gene appears to be allelic with lexC, a gene with a proposed role in regulating inducible deoxyribonucleic acid repair.
摘要
大肠杆菌单链结合蛋白基因的突变导致温度敏感型脱氧核糖核酸复制（R. R. 迈耶、J. 格拉斯伯格和A. 科恩伯格，《美国国家科学院院刊》76:1702 - 1705, 1979年）。该突变体（ssb - 1）对紫外线照射也更敏感，且重组活性约为正常的五分之一。因此，单链结合蛋白与修复、重组以及复制均有关联。ssb的突变位于遗传图谱上90.8分钟处的uvrA和melA之间。ssb基因似乎与lexC等位，lexC是一个在调控诱导型脱氧核糖核酸修复中起作用的基因。
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