Go Se-Il, Lee Won Sup, Kang Myung Hee, Kim In-Suk, Kim Dong Chul, Lee Jeong-Hee
Department of Internal Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, Korea.
Korean J Hematol. 2012 Jun;47(2):146-9. doi: 10.5045/kjh.2012.47.2.146. Epub 2012 Jun 26.
Subcutaneous panniculitis-like T-cell lymphoma (SPTL) is a distinctive lymphoma characterized by an infiltration of subcutaneous tissue by neoplastic cytotoxic T cells. There was no distinction between TCR alpha/beta phenotype and TCR gamma/delta phenotype, and anthracycline-based chemotherapy was usually used for both. Here, we report a patient with recurrent SPTL who achieved a second long-term complete remission by repeated cyclosporine A (CsA) treatment. From 2000 to 2001, the patient received anthracycline-based combination chemotherapy. However, the treatment did not induce long-term remission. In 2002, he received cyclosporine treatment for about 6 months. This resulted in a 5-year remission that ended in relapse in 2008. He received CsA treatment once again and attained a second long-term remission. This case suggests that re-treatment with CsA can be a good option for relapsed SPTL cases and can result in long-term remission.
皮下脂膜炎样T细胞淋巴瘤（SPTL）是一种独特的淋巴瘤，其特征为肿瘤性细胞毒性T细胞浸润皮下组织。TCRα/β表型和TCRγ/δ表型之间无差异，基于蒽环类药物的化疗通常用于这两种表型。在此，我们报告1例复发性SPTL患者，通过重复使用环孢素A（CsA）治疗实现了第二次长期完全缓解。2000年至2001年，该患者接受了基于蒽环类药物的联合化疗。然而，该治疗未诱导长期缓解。2002年，他接受了约6个月的环孢素治疗。这导致了5年的缓解期，最终于2008年复发。他再次接受CsA治疗并获得了第二次长期缓解。该病例提示，对于复发的SPTL病例，再次使用CsA治疗可能是一个不错的选择，并且可导致长期缓解。
