Lin Xiaohong, Tang Xiangyu, Jiang Qiong, Liu Qing, Lin Zhang, Lin Junhua, Chen Lianglong, Hong Huashan
Fujian Institute of Coronary Artery Disease, Fujian Medical University, Fuzhou, PR China.
Clin Lab. 2012;58(5-6):539-44.
Coronary artery disease (CAD) is a major vascular complication of type 2 diabetes mellitus (T2DM) and reveals high mortality. Serum levels of chemerin have been suggested to be involved in glucose and lipid metabolism and associated with several cardiovascular factors. The aim of this study is to investigate the association of serum chemerin levels with the presence of CAD in patients with T2DM.
Serum levels of chemerin were determined in 286 patients with T2DM who underwent coronary angiography for the evaluation of CAD and 128 healthy subjects. The T2DM patients group included 150 patients with CAD and 136 patients without CAD.
Serum chemerin levels were significantly higher in T2DM patients with CAD compared with those without CAD and healthy controls. However, there was no significant difference in the levels of serum chemerin between T2DM patients without CAD and healthy controls. Multivariable logistic regression analysis revealed that serum chemerin levels were an independent determinant of the presence of CAD in patients with T2DM (OR 1.057, 95% CI 1.040 to 1.075; p < 0.001). In addition, linear regression analysis showed that serum chemerin levels were positively correlated with body mass index, systolic blood pressure, homeostasis model assessment of insulin resistance, and serum triglycerides.
There is an independent association between serum levels of chemerin and the presence of CAD in patients with T2DM.
冠状动脉疾病（CAD）是2型糖尿病（T2DM）的主要血管并发症，且死亡率很高。有研究表明，血清趋化素水平与糖脂代谢有关，并与多种心血管因素相关。本研究旨在探讨T2DM患者血清趋化素水平与CAD存在情况之间的关联。
对286例因评估CAD而接受冠状动脉造影的T2DM患者和128例健康受试者测定血清趋化素水平。T2DM患者组包括150例CAD患者和136例无CAD患者。
与无CAD的T2DM患者及健康对照相比，有CAD的T2DM患者血清趋化素水平显著更高。然而，无CAD的T2DM患者与健康对照之间血清趋化素水平无显著差异。多变量逻辑回归分析显示，血清趋化素水平是T2DM患者CAD存在情况的独立决定因素（比值比1.057，95%置信区间1.040至1.075；p<0.001）。此外，线性回归分析表明，血清趋化素水平与体重指数、收缩压、胰岛素抵抗稳态模型评估及血清甘油三酯呈正相关。
T2DM患者血清趋化素水平与CAD的存在之间存在独立关联。
