通过腈稳定的铵叶立德的五步合成（±）-罂粟碱。

A five-step synthesis of (±)-tylophorine via a nitrile-stabilized ammonium ylide.

机构信息

Institute of Organic Chemistry, University of Mainz, Duesbergweg 10-14, D-55128 Mainz, Germany.

出版信息

J Org Chem. 2012 Aug 3;77(15):6620-3. doi: 10.1021/jo3011045. Epub 2012 Jul 19.

Abstract

The Stevens rearrangement of a nitrile-stabilized ammonium ylide is the key step of a very short and practical synthesis of the phenanthroindolizine alkaloid (±)-tylophorine. The method requires only five linear steps and is devoid of any protecting group manipulations.

摘要

腈稳定的铵叶立德的史蒂文斯重排反应是（±）-罂粟碱菲吲哚里嗪生物碱的极短实用合成的关键步骤。该方法只需五个线性步骤，且无需任何保护基操作。