Couto Rafael A, Hassanein Aladdin H, Maclellan Reid A, Greene Arin K
Department of Plastic and Oral Surgery, Vascular Anomalies Center, Children's Hospital Boston, Harvard Medical School, Boston, MA02115, USA.
Pediatr Dermatol. 2013 May-Jun;30(3):e14-5. doi: 10.1111/j.1525-1470.2012.01779.x. Epub 2012 Jul 12.
Infantile hemangioma is the most common tumor of infancy, affecting approximately 5.0% of Caucasians. We present the unlikely occurrence of four siblings with infantile hemangiomas; there was no family history of the tumor. One child was low birth weight, there was one set of twins, and three infants had multiple lesions. The estimated probability of four consecutive children having this phenotypic expression of infantile hemangioma is 1/4,232,804.
婴儿血管瘤是婴儿期最常见的肿瘤，约5.0%的白种人受其影响。我们报告了一个不太可能发生的情况：四个兄弟姐妹都患有婴儿血管瘤，且家族中无该肿瘤病史。其中一个孩子出生时体重偏低，有一对双胞胎，三个婴儿有多处病损。四个孩子连续出现婴儿血管瘤这种表型的估计概率为1/4,232,804。
