Kawai Y, Midorikawa A, Sugimoto A, Futamura A, Sobue G, Kawamura M
Department of Neurology, Showa University School of Medicine, Tokyo, Japan.
Neurocase. 2013 Aug;19(4):408-15. doi: 10.1080/13554794.2012.690425. Epub 2012 Jul 11.
Apraxia is a well-known disorder of praxis and is caused mainly by damage to the left parietal lobe. We presented two cases of neurodegenerative disease with a distinct disorder of praxis, predominantly involving left parietal lobe. While both patients could understand what they should do, they were not able to initiate action and often stopped during execution of actions. They had no apraxia and no temporal and spatial errors on praxis. Magnetic resonance imaging of both patients showed atrophy of the left parieto-occipital and temporo-occipital lobes, and single photon emission computed tomography showed hypoperfusion in the same lobes. Moreover, one of our cases, using [11C] PIB PET, demonstrated increased uptake in the cerebral cortices, suggesting Alzheimer's disease. The symptoms described are different from other disorders of praxis and similar to bradyphrenia or freezing.
失用症是一种众所周知的运用障碍，主要由左侧顶叶受损引起。我们报告了两例神经退行性疾病患者，他们存在明显的运用障碍，主要累及左侧顶叶。虽然两名患者都明白自己应该做什么，但他们无法启动动作，并且在执行动作过程中经常停顿。他们没有失用症，在运用方面也没有时间和空间错误。两名患者的磁共振成像均显示左侧顶枕叶和颞枕叶萎缩，单光子发射计算机断层扫描显示相同脑叶灌注不足。此外，我们的其中一例患者使用[11C] PIB PET检查，显示大脑皮质摄取增加，提示患有阿尔茨海默病。所描述的症状与其他运用障碍不同，类似于思维迟缓或动作迟缓。
