Department of Clinical Microbiology, Copenhagen Ø, Denmark.
J Cyst Fibros. 2013 Jan;12(1):42-8. doi: 10.1016/j.jcf.2012.06.005. Epub 2012 Jul 10.
Staphylococcus aureus is an important pathogen in CF. Centre prevalence of intermittent colonization and chronic S. aureus infections and the effectiveness of an anti-S. aureus eradication strategy was assessed.
All airway cultures from 300 patients in a 2-year period were retrieved and all anti-S. aureus antibiotic treatments were evaluated for treatment success. Chronic infection was defined as a positive culture of S. aureus in 50% or more of the months each year. Change in FEV(1) following 2weeks of treatment of S. aureus was assessed in clinically stable patients. Primary outcome was S. aureus eradication at next clinical visit and number of patients chronically infected.
The yearly prevalence of S. aureus intermittent and chronic infection was 47% and 14%, respectively. Eradication was successful at the next clinical visit in 61% of the standard treatment and 53% of the prolonged treatments, respectively. FEV(1) improved significantly following anti-S. aureus treatment (3.3%, p<0.0001).
Our anti-S. aureus eradication strategy in CF patients resulted in a low prevalence of chronic infections and high treatment efficacy. Furthermore, anti-staphylococcal treatment may be associated with a short-term improvement in lung function.
金黄色葡萄球菌是 CF 中的重要病原体。评估了间歇性定植和慢性金黄色葡萄球菌感染的中心流行率，以及抗金黄色葡萄球菌根除策略的有效性。
检索了 2 年内 300 名患者的所有气道培养物，并评估了所有抗金黄色葡萄球菌抗生素治疗的治疗成功率。慢性感染定义为每年金黄色葡萄球菌阳性培养物占 50%或以上的月份。在临床稳定的患者中，评估了金黄色葡萄球菌治疗 2 周后 FEV1 的变化。主要结局是下一次临床就诊时金黄色葡萄球菌的根除率和慢性感染患者的数量。
金黄色葡萄球菌间歇性和慢性感染的年患病率分别为 47%和 14%。标准治疗和延长治疗的下一次临床就诊时的根除成功率分别为 61%和 53%。抗金黄色葡萄球菌治疗后 FEV1 显著改善（3.3%，p<0.0001）。
我们在 CF 患者中实施的抗金黄色葡萄球菌根除策略导致慢性感染的患病率较低，治疗效果较高。此外，抗葡萄球菌治疗可能与肺功能的短期改善相关。
