Cruz A, Parkinson A J, Hall D, Bulkow L, Heyward W
Arctic Investigations Program, Center for Infectious Diseases, Centers for Disease Control, Anchorage, Alaska.
Arctic Med Res. 1990 Oct;49(4):175-9.
A retrospective study was carried out to determine the effect of common childhood infectious diseases on the hemoglobin level of a cohort of Alaskan Eskimo children born between 1960 and 1962. Hemoglobin and health records were available on 308 children between 6-11 and 12-17 months of age. Additional records were available on 187 of these children at 18-23 months of age. Episodes of chickenpox, measles, pertussis, and lower respiratory infections were reviewed. Between 38 and 50% of infants between 6 and 23 months of age had hemoglobin levels below 11.0 g/dl. The mean hemoglobin level of infants 6-11 and 12-17 months of age decreased with increasing number of total infectious episodes occurring within the 3 months before hemoglobin measurement. This trend was not apparent for infants in the 18-23 months age interval nor were low hemoglobins predictive of illness during the 3 months after the hemoglobin determination. At the 6-11 and 12-17 month age interval the number of lower respiratory infectious were most significantly associated with a decreased hemoglobin value. These observations are consistent with more recent reports that document iron deficiency anemia among children with antecedent infections and again emphasize the role of infection in the development and maintenance of anemia in children about 1 year of age.
开展了一项回顾性研究，以确定常见儿童传染病对1960年至1962年出生的一群阿拉斯加爱斯基摩儿童血红蛋白水平的影响。有308名6至11个月和12至17个月大儿童的血红蛋白和健康记录。其中187名儿童在18至23个月大时还有额外记录。对水痘、麻疹、百日咳和下呼吸道感染发作情况进行了回顾。6至23个月大的婴儿中，38%至50%的血红蛋白水平低于11.0 g/dl。6至11个月和12至17个月大婴儿的平均血红蛋白水平随着血红蛋白测量前3个月内发生的总感染发作次数增加而降低。这种趋势在18至23个月龄婴儿中不明显，血红蛋白水平低也不能预测血红蛋白测定后3个月内的疾病情况。在6至11个月和12至17个月龄时，下呼吸道感染次数与血红蛋白值降低最显著相关。这些观察结果与最近关于先前感染儿童缺铁性贫血的报告一致，并再次强调了感染在1岁左右儿童贫血发生和维持中的作用。
